Metabolomics is the science of measuring and statistically analyzing low-molecular-weight metabolites within biological specimens. Since metabolites change in response to external stimuli, such as diet and chemical exposure, monitoring these changes over time can provide insights into physiological conditions, both healthy and diseased.
Metabolomics allows for the simultaneous profiling of thousands of metabolites, far exceeding the capabilities of traditional laboratory techniques, making it a valuable tool for understanding complex physiological processes in both animal and plant biology.
Metabolomics workflows are more complex compared to genomics and proteomics workflows because there is no single technology capable of analyzing the entire metabolome.
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Analyzing molecules with dissimilar physicochemical properties requires separate workflows for different classes of metabolites (e.g., polar vs. non-polar). |
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Metabolite levels can change during sample preparation due to residual enzymatic activity unless they are extracted according to strict protocols using low temperatures and organic solvents. |
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International quality assurance and quality control (QA/QC) practices in metabolomics necessitate the preparation of different types of QC samples during the extraction of study samples. |
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Large-scale metabolomics studies with thousands of samples must achieve the repeatability and processing requirements that are standard in the manual preparation of small studies. |
Our liquid handlers play a crucial role in metabolomics research by automating sample preparation, increasing throughput, and ensuring precision and reproducibility. Moreover, they streamline complex workflows, from sample extraction to compound identification, enabling researchers to focus on data analysis and discovery. With our advanced automation solutions, metabolomics research becomes more efficient and reliable, driving scientific advancements forward.
“Having conducted research in metabolomics for almost 20 years, I’ve experienced firsthand the labor intensive nature of metabolite extractions as well as the importance of repeatable extractions to achieve high data quality. Establishing our extraction protocols on the Biomek i7 has opened a new horizon for high-throughput metabolomics, enabling the preparation of thousands of cell extracts for mass spectrometric analysis within just a few days”
Mark R. Viant, Ph.D.
Executive Director of Phenome Centre Birmingham
Team Leader of Metabolomics & Systems Toxicology Laboratory
University of Birmingham, UK
Our automated liquid handlers have proven invaluable to metabolomics researchers by simplifying complex sample preparation workflows. From sample extraction to compound identification, our solutions help you overcome challenges associated with manual processes and free up more time for you to dedicate to data analysis and discovery.
Beckman Coulter Life Sciences is one of the many Danaher life sciences businesses. Others include SCIEX, Phenomenex, Cytiva, IDBS, Integrated DNA Technologies, Leica Microsystems and Molecular Devices. Together, we bring you an unrivaled range of expertise and resources, fueling groundbreaking advancements in metabolomics research.
Semi-automated extraction of cell and tissue samples for multi-omic analysis using the Biomek i7 Hybrid Workstation
Fully Automated Determination of Cannabinoids on a Biomek i7 Hybrid Workstation Using Positive Pressure Solid Phase Extraction
Automated Solid Phase Extraction Based Determination of Cannabinoids in Saliva using Biomek i7 Hybrid Workstation
Fully Automated Sample Preparation for the Determination of Vitamin D on Biomek i7 Hybrid Using Advanced Protein Precipitation Combined with Positive Pressure Solid Phase Extraction
Fully Automated Sample Preparation for the Determination of Vitamin D on Biomek i7 Hybrid Workstation using Advanced Sample Cleanup with Phree Phospholipid Removal Cartridges
Miniaturized and High-Throughput Metabolic Stability Assay Enabled by the Echo Liquid Handler
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