Automate & Accelerate Your Cell Line Development Workflow

As biologics research continues to evolve and gain prominence in therapy development for disease states, the need for reliable and robust cell lines will greatly increase.

Traditionally, cell line development has been achieved manually, limiting it to low-throughput applications and making it susceptible to variability caused by human error and contamination.

 

Automating the cell line development workflow with
Beckman Coulter Liquid Handlers:

  • Removes potential for human error through automation
  • Optimizes media conditions that are critical for cell lines
  • Reduces potential contamination
  • Increases throughput needed for vaccines, antibody production, recombinant therapies and drug screening
  • Enables complete walk-away solution while efficiently managing your data stream
  • Reduces FTE utilization for repetitive tasks related to transfection or fusion, expansion, screening, clone selection and titer assays

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WATCH ON DEMAND

Single cell antibody discovery using ‘Islands of Automation’

Paul Anderson
Director - Biologics Discovery Automation
Eli Lilly

In this webinar, Paul Anderson, Director - Biologics Discovery Automation at Eli Lilly will focus on the automated systems that have been developed as part of this platform. This highly automated approach to antibody discovery has enabled Lilly to meet aggressive timelines and dramatically increase throughput while allowing flexibility for future changes to its process.

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Increase Hits & Confirm Leads

Automation can overcome many cell line development challenges including:

  • Sample sterility
  • Consistent pipetting of semi-solid media
  • Monoclonal cell plating by limiting dilution
  • High-throughput limiting dilution
  • Hit picking for IgG analysis and cell expansion

Biomek Automated Workstations enable:

  • Microliter-to-milliliter transfers
  • Nucleic acid isolations from primary sample tubes to preparing sequence-ready libraries

Echo Acoustic Liquid Handlers allow:

  • Nanoliter-to-microliter transfers
  • Reduction of reaction costs through reduced reaction volumes and acoustic tipless transfers
  • Fast any-well-to-any-well transfers enabling up to 10 times faster DNA/RNA normalization, barcoding or normalization and pooling of the libraries

One Trusted Partner for Automated Liquid Handlers, Consumables and Service

Acoustic and tip-based technologies for low- to high-volume transfers

Reproducibility
  • Custom and standard automation solutions to remove process variability
  • Best-in-class instruments
  • Remove potential for human error through automation
Time Savings
  • Increase throughput of cell lines developed
  • Decrease time required to produce clones
  • Reduce FTE utilization for repetitive tasks
Efficiency
  • Increase number of cell lines developed
  • Reduce quantity of materials used
  • Instrument flexibility for multiple workflow stages
Data Integrity
  • Systems come with validation and data integrity functions for GMP compliance
  • Secure connectivity across internal data infrastructure

Applications

Explore the possibilities

The real-world benefits provided by our technologies are realized only through their application.

Access
App Notes

Explore how to apply our liquid handling solutions for your CLD workflows

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Case Studies

Learn how other customers are leveraging our solutions to automate their CLD workflows

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Publications

Explore peer-reviewed publications from leading journals where scientists have cited our solutions in their CLD workflows

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Webinars

View CLD related webinars from highly acclaimed researchers and industry professionals from around the world


Customer Story

Don't just take our word for it!

SINTEF Industry, Norway discusses the benefits of automating cell line development workflows with Beckman Coulter Liquid Handlers.

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Our Products

Do more with less. CELL-A-BRATE!

Biomek i7 Hybrid Workstation

Product No: C23340

For high-throughput laboratories, the Biomek i7 Workstation provides a complete walkaway solution to maximize return on investment (ROI).

  • 45 deck positions
  • 0.5 - 5,000 µL pipetting volume range
  • Single or dual heads

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Echo 650
Liquid Handler

Product No: 001-10080

For medium- to high-throughput screening applications, the Echo 650 series provides contactless automation to enable scientific discovery.

  • Enables transfer of as little as 2.5 nL from 384-well and 1536-well microplates
  • Available upgrade packages that enable the addition of Echo-qualified sample tubes

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Echo 525
Liquid Handler

Product No: 001-10080

For medium- to high-throughput screening applications, the Echo 525 series provides contactless automation to enable scientific discovery

  • Highly precise and accurate low volume transfers enabling assay miniaturization
  • Suite of Echo Software Applications guide creation of complex protocols

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Biomek i7 Hybrid Workstation Enclosed

Product No: C23339

For high-throughput laboratories, the Biomek i7 Workstation provides a complete walkaway solution to maximize return on investment (ROI).

  • 45 deck positions
  • 0.5 - 5,000 µL pipetting volume range
  • Single or dual heads

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Biomek i5 Span-8 Workstation

Product No: C23341

For medium- to high-throughput laboratories, the Biomek i5 Workstation provides scalable automation that grows with changing workflow needs.

  • 25 deck positions
  • 0.5 - 5,000 µL pipetting volume range
  • Single head

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Biomek i5 Span-8 Workstation Enclosed

Product No: C23342

For medium- to high-throughput laboratories, the Biomek i5 Workstation provides scalable automation that grows with changing workflow needs.

  • 25 deck positions
  • 0.5 - 5,000 µL pipetting volume range
  • Single head

Request a Quote


Cell Line Development Resources

Some more content exclusively for you

Access Brochure

Access product and portfolio overviews, informational flyers & more to support your CLD workflows

Download Interactive eBook

Digital guide on automated solutions for CLD library prep

See Integrated Solutions

Transform liquid handlers into CLD workflow solutions by integrating more than 300 third-party devices from over 60 manufacturers to develop multi-device robotic system to increase your lab's throughput, accuracy and scalability

View Posters

See CLD related posters presented by Beckman Coulter scientists at conferences, meetings and symposia around the world

Explore Reagents

Drive optimum performance, flexibility and scalability on your choice of platforms with our reagent portfolio powered by Solid Phase Reversible Immobilization (SPRI) technology—widely known as the science behind AMPure XP

View Software

Get reliable results without the need to learn automation language. Simplify the complexity of sample and data handling through our software package add-ons to meet your CLD workflow needs.

See Tips

Use pipette tips from Beckman Coulter Life Sciences for quality you can rely on

Watch Videos

Watch videos that dive into our portfolio of flexible automated liquid handling solutions to automate your CLD workflows


Customer Support

When it comes to world-class support, wherever you are, we're behind you.

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Increase Your Hits. Scale and grow your lab by automating your cell line development workflows. Contact us today!

These products are not intended or validated for use in the diagnosis of disease or other conditions. © 2022 Beckman Coulter, Inc. All rights reserved. Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein, including Biomek, are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries. Echo and Access are trademarks or registered trademarks of Labcyte Inc. in the United States and other countries. Labcyte is a Beckman Coulter company. All other trademarks are the property of their respective owners.

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