The Optima AUC* is a versatile method to characterize the hydrodynamic behaviors of biological (and other samples) in solution. It is based on the principles of sedimentation - the passage down a tube in a centrifugal field. The Optima AUC* instrument can detect samples based on UV-vis absorbance as well as refractive index.
Unique Advantages of AUC* Analysis
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| Nanoparticles |
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|---|---|
| Quantum Dots | |
| RNA Aptamers | |
| Polysaccharides | |
| Viral Vectors for Gene Therapy |
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| Membrane Protein-Lipid Interactions | |
| Protein-Protein Interactions |
|
| Protein-Nucleic Acid Interactions |
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| and many more! |
In one experiment, AUC* technology can provide more answers to critical questions than any other comparable technique:
Questions to understand the behavior of macromolecules** :
James J. Marti, Ph.D.
James Marti is Senior Scientist and Outreach Coordinator for the Minnesota Nano Center, where he manages two research laboratories focusing on nanomaterials and the biological applications of nanotechnology. Prior to joining the MNC, Dr. Marti conducted research on nanoparticles for academic and government labs, and served as R&D director for several small companies with a nanotechnology product focus. A physicist by training, his primary scientific interest has been the physics and chemistry of micron-and nanometer-scale particles, particle systems, and related materials.
Borries Demeler, Ph.D.
Borries Demeler, Ph.D. is the Canada 150 Research Chair for Biophysics at the University of Lethbridge in Canada, with cross appointments at UT Health in San Antonio and at the University of Montana. Dr. Demeler is well known for his contributions to the field of solution biophysics, in particular for the hydrodynamic modeling of analytical ultracentrifugation experiments. He has published over 190 manuscripts and book chapters. He is the principal author of the open source UltraScan software, and has created a world-wide network of laboratory information management systems (LIMS servers) to support high resolution hydrodynamic modeling with high-performance computing. Together with Prof. Helmut Coelfen in Germany he has pioneered the use of multi-wavelength analytical ultracentrifugation for the study of hetero-interacting systems and measuring binding stoichiometry in the solution state. At the University of Lethbridge he manages the Canadian Center for Hydrodynamics. His NIH-funded research group at the University of Montana develops GMP validation and automation of the analytical ultracentrifugation technique. He is the CEO of AUC Solutions LLC based in Houston Texas, where he provides consulting services to the biopharma industry.